Single Fluid Heating Cooling System

Traditional Heating & Cooling Systems
Active Pharmaceutical Ingredient (API) manufacturing involves batch reaction, work-up, distillation, crystallization, hydrogenation, layer separation, filtration and drying as unit processes. Again, batch reaction involves heating and cooling stages ranging from -50°C to +250°C. Traditionally, this was being done with multiple utilities such as chilled brine, chilled water, cooling water, hot water, low pressure steam, high pressure steam, thermic fluid etc.

• Different heat transfer fluids (HTFs) may require separate coils, heating and cooling jacket zones or external heat exchangers.
• Time consuming changeover of HTFs and associated risks of human error.
• Cross contamination of HTFs.
• Multiple utilities can corrode the reactor jacket.
• Condensate recovery is not feasible.
• Inefficient management of HTFs leading to inaccurate temperature control.
• Process parameter deviations adversely affect product quality.
• Complicated mechanical design, and Increases capital/maintenance costs.

Single fluid heating cooling systems (SFHC) / Temperature Control Unit (TCU) are coming-up as an ideal solution to overcome most of the limitations with traditional multiutility based heat transfer and control system. where high accuracy and wide temperature ranges are critical for the development of new compounds and API’s.

How it Works?
Single fluid heating cooling system is normally connected to a single reactor, where the Temperature of the system is varied as per the process requirement, Thus maintaining the constant temperature difference between the process and fluid temperature.
This gives precise control over heating and cooling cycle. Thus, not only the temperature is controlled as a critical process parameter but also the heating-and-cooling time is controlled as a critical parameter. This results in batch-to-batch consistency and higher yield.

• Temperature range - 35°c to 250°c with precise temperature control, +/-1°c.
• Rapid heating or cooling, reducing batch time.
• All wetted parts are in stainless steel.
• Totally enclosed skid & mounted on wheels for easy mobility.
• No switching between jacket service fluids, preventing cross- contamination, corrosion or thermal shocks to the vessel.
• Remote control panel with flameproof enclosures (suitable for gas group IIA, IIB)
• Automation - System is controlled by PLC system which can be integrated with SCADA

• Accurate temperature control to +/-1°C without risk to your reactor.
• Rapid heating and chilling profiles can be designed, reducing batch times.
• Repeatability and accurate recordable.
• Measurement for meeting FDA requirements.
• Programmable heating and cooling ramps for accurate unsupervised operations.
• No switching between jacket service fluids, preventing cross contamination, corrosion or thermal shocks to the vessel.
• Smooth, continuous temperature control, with no gaps because there is no fluid changeovers.
• No interruption of process and no hot spots, resulting in higher product yields and quality. Off batches are minimized, if not eliminated.
• Savings on expensive raw materials can be made because the yield is maximized without adding excess reactions.
• Suitable for the very cold operating temperatures required by today’s new chemical formulae and reactions.
• Fully automatic capability, hence less manpower required.

• SFHC / TCU finds its purpose in various temperature based applications like,
• Crystallization Reactions – For better productivity
• Non-Aqueous Reactions: Critical application where Aqueous utilities are to be not used for heating/cooling, which leads to hazardous conditions (e.g. reactions which involve materials like Sodium) – For Safety
• metal Reactions – For better batch-to-batch repeatability
• Alternate Heating & cooling process application (where utility change over is a wastage of time & tiresome job)
• Applications where sudden temperature rise, causing thermal shocks.
• Multi product plant

Why Us?
• Pioneers in SFHC / TCU for the last 10 years.
• Pharma Process domain expertise.
• Prompt service support with dedicated servicing team.
• Swift response for the customer queries through dedicated technical team.
• Customer friendly.
• Competitive pricing.
• Right & Reputed international component selection.
• Better delivery periods.
• In-house chemical process engineers.

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